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Nephroti Scyndrome

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6 Kinds of Refractory Nephrotic Syndrome

6 Kinds of Refractory Nephrotic Syndrome
In 10 years, about 30% of patients with refractory nephrotic syndrome will develop uremia and eventually survive on dialysis. Do you want to know whether your nephrotic syndrome is refractory or not? Go on reading to learn more information.

1. The older the patients are, the more difficult the treatment

Elderly patients with nephrotic syndrome are often more difficult to treat than adolescent nephrotic syndrome, and adult nephrotic syndrome is more difficult to treat than children. Because the causes of nephrotic syndrome in the elderly are more complex, such as metabolic diseases, tumor-related and connective tissue diseases. At the same time, the types of nephrotic syndrome in the elderly may be more serious, such as membranous nephropathy, membranous proliferative nephritis and FSGS, while nephrotic syndrome in adolescents and children is mostly caused by minimal change disease or minor glomerular lesions.

2. Combined with macroscopic hematuria or obvious microscopic hematuria, the treatment difficulty increases.

Nephrotic syndrome is characterized by "highly edema, 24 hours urinary protein quantitative (adult more than 3.5 grams), hyperlipidemia, and hypoproteinemia (less than 30 g/L)". Some kidney patients may also have gross hematuria or obvious microscopic haematuria. This condition is more intractable.

3. When kidney function declines, and blood creatinine rises, treatment difficulty is bigger.

For example, membranous nephritis, crescent nephritis, etc., when renal function declines and blood creatinine increases, the treatment difficulty of the patients will increase dramatically, which is far more difficult to treat than nephrotic syndrome combined with hematuria and nephrotic syndrome in the older patients.

4. When the combined blood pressure is significantly higher, the treatment is more difficult.

In most cases, if blood pressure remains high and is difficult to drop to normal, it may sometimes be more difficult to treat than nephrotic syndrome with renal impairment and eventually progress to uremia.

5. Increased levels of immunoglobulin IgG and alfa globulin make treatment more difficult.

The rise of two immunological examination indicators, immunoglobulin IgG and γ globulin level often suggests that this nephrotic syndrome is more secondary than primary, and secondary nephrotic syndrome is usually caused by connective tissue diseases, such as lupus nephritis, which is significantly more difficult to treat.

6. The increased α and β microglobulin and NAG-U in urine make treatment more difficult.

For those who have been found to be significantly elevated in the urine protein analysis, the urine analysis of α and β microglobulin and NAG-U are often found to be associated with severe tubulointerstitial lesions and severe damage to the renal glomeruli and tubulointerstitial lesions, which is also one of the factors indicating that nephrotic syndrome is difficult to treat.

The above 6 cases are relatively difficult to treat, but it does not mean it is not treatable. If you are detected to have refractory nephrotic syndrome, you should cooperate with your doctor for standard treatment actively. In our hospital, we use Toxin-Removing Treatment, which can help you restore renal function and keep uremia far away.

For more information on Nephrotic Syndrome treatment, please leave a message below or contact online doctor.

Tag: Nephrotic Syndrome Nephrotic Syndrome Basics
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